Medications That Interfere With Hemostasis (NSAIDs, Aspirin, Warfarin, etc.) - Serotonin release by platelets plays a vital duty in hemostasis. Epidemiological research studies of the case-control and pal layout that have actually shown an association in between usage of psychotropic medicines that meddle with serotonin reuptake and the event of top gastrointestinal bleeding have actually likewise revealed that simultaneous usage of an NSAID or pain killers potentiated the risk of bleeding. Therefore, clients must be cautioned regarding using such medications concurrently with citalopram.
Cimetidine - In subjects who had received 21 days of 40 mg/day citalopram, integrated management of 400 mg/day cimetidine for 8 days led to a boost in citalopram AUC as well as Cmax of 43 % and also 39 %, specifically. The clinical relevance of these searchings for is unidentified.
Digoxin - In topics who had gotten 21 days of 40 mg/day citalopram, combined management of citalopram and digoxin (solitary dose of 1 mg) did not significantly affect the pharmacokinetics of either citalopram or digoxin.
Lithium - Coadministration of citalopram (40 mg/day for 10 days) and lithium (30 mmol/day for 5 days) had no considerable impact on the pharmacokinetics of citalopram or lithium. Plasma lithium levels need to be monitored with appropriate modification to the lithium dose in conformance with basic scientific practice. Care must be worked out when citalopram and lithium are coadministered considering that lithium could boost the serotonergic results of citalopram.